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      南京大展差示扫描量热仪(DSC)在药物研发与生产分析中的应用
      2017-09-01 14:51:21

      药品的研发与生产必须监控其物化性质,如纯度、晶型、稳定性和安全性,以确保药物具?#24615;?#26399;的药性。众所周知,有机化合物包括药品常常具有多种结构及晶态,这势必影响到药品的加工条件、期稳定性、衰变及生物投递能力。药品的最终组成中包含了多种活性组份以及它们之间相互作用而生成的产物,当然还有赋形剂、水分、药片涂层等,十分复杂。因此对其全面的表征也变得越来越重要,其中最理想的测试方法之一就是热分析。

      热分析具有用量少、方法灵敏、快速的特点,在较短的时间内可获得需要复杂技术或长期研究才能得到的各?#20013;?#24687;。差示扫描量热仪(DSC )是目前在医药领域应用最广的热分析仪之一,DSC 通过测量药物热焓和温度随程序温控的变化,具体可以研究的信息如: 1、药物纯度 2、药物的多晶及亚稳态、无定形态的研究 3、优化冷冻干燥 4、脂质检测、蛋白质变性。

      DSC-100 差示扫描量热仪

      该仪器已获国家专利,专利号201120337217 3。 产?#26041;?#32461;: DSC测量的是与材料内部热转变相关的温度、热流的关系,应用范围非常广,特别是材料的研发、性能检测与质量控制。材料的特性:如玻璃化转变温度。冷结晶、相转变、熔融、结晶、热稳定性、固化 交联、氧化诱导期等,都是DSC的研发领域。

         
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